Antifibrotic action of Yifei Sanjie formula enhanced autophagy via PI3K-AKT-mTOR signaling pathway in mouse model of pulmonary fibrosis.
Identifieur interne : 000A75 ( Main/Exploration ); précédent : 000A74; suivant : 000A76Antifibrotic action of Yifei Sanjie formula enhanced autophagy via PI3K-AKT-mTOR signaling pathway in mouse model of pulmonary fibrosis.
Auteurs : Jing-Ze Yu [République populaire de Chine] ; Yi Ying [République populaire de Chine] ; Yang Liu [République populaire de Chine] ; Chun-Bin Sun [République populaire de Chine] ; Chen Dai [République populaire de Chine] ; Shan Zhao [République populaire de Chine] ; Shou-Zheng Tian [République populaire de Chine] ; Jing Peng [République populaire de Chine] ; Ni-Ping Han [République populaire de Chine] ; Jia-Li Yuan [République populaire de Chine] ; Jin-Yuan Yan [République populaire de Chine] ; Zhong-Shan Yang [République populaire de Chine]Source :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [ 1950-6007 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Autophagie (), Autophagosomes (métabolisme), Autophagosomes (ultrastructure), Collagène (métabolisme), Facteur de croissance transformant bêta-1 (métabolisme), Fibrose pulmonaire (), Fibrose pulmonaire (anatomopathologie), Fibrose pulmonaire (métabolisme), Fibrose pulmonaire (traitement médicamenteux), Humains, Inflammation (), Inflammation (anatomopathologie), Modèles animaux de maladie humaine, Mâle, Médicaments issus de plantes chinoises, Phosphatidylinositol 3-kinases (métabolisme), Phosphorylation (), Poumon (anatomopathologie), Protéines proto-oncogènes c-akt (métabolisme), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal.
- MESH :
- anatomopathologie : Fibrose pulmonaire, Inflammation, Poumon.
- métabolisme : Autophagosomes, Collagène, Facteur de croissance transformant bêta-1, Fibrose pulmonaire, Phosphatidylinositol 3-kinases, Protéines proto-oncogènes c-akt, Sérine-thréonine kinases TOR.
- traitement médicamenteux : Fibrose pulmonaire.
- Animaux, Autophagie, Autophagosomes, Fibrose pulmonaire, Humains, Inflammation, Modèles animaux de maladie humaine, Mâle, Médicaments issus de plantes chinoises, Phosphorylation, Transduction du signal.
English descriptors
- KwdEn :
- Animals, Autophagosomes (metabolism), Autophagosomes (ultrastructure), Autophagy (drug effects), Collagen (metabolism), Disease Models, Animal, Drugs, Chinese Herbal, Humans, Inflammation (complications), Inflammation (pathology), Lung (pathology), Male, Phosphatidylinositol 3-Kinases (metabolism), Phosphorylation (drug effects), Proto-Oncogene Proteins c-akt (metabolism), Pulmonary Fibrosis (complications), Pulmonary Fibrosis (drug therapy), Pulmonary Fibrosis (metabolism), Pulmonary Fibrosis (pathology), Signal Transduction, TOR Serine-Threonine Kinases (metabolism), Transforming Growth Factor beta1 (metabolism).
- MESH :
- chemical , metabolism : Collagen, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases, Transforming Growth Factor beta1.
- complications : Inflammation, Pulmonary Fibrosis.
- drug effects : Autophagy, Phosphorylation.
- drug therapy : Pulmonary Fibrosis.
- metabolism : Autophagosomes, Phosphatidylinositol 3-Kinases, Pulmonary Fibrosis.
- pathology : Inflammation, Lung, Pulmonary Fibrosis.
- ultrastructure : Autophagosomes.
- Animals, Disease Models, Animal, Drugs, Chinese Herbal, Humans, Male, Signal Transduction.
Abstract
Pulmonary fibrosis (PF) is a crippling disease characterized by progressive dyspnea and associated with a high mortality rate, but its origin is unknown and there is no effective treatment. Yifei Sanjie formula (YFSJF) is a Chinese medicine that is widely used for treatment of respiratory systems disease. However, the molecular basis for the function of YFSJF has not been determined. Here we investigate the contribution of YFSJF in BLM-induced PF mice. Administration with YFSJF significantly alleviated the degree of BLM-induced collagen I and III deposition and the inflammatory injuring in the lungs and suppressed hydroxyproline release in PF animals. The active components of YFSJF are comprised with flavonoid, amino acids, saponins, oligosaccharide, organic acid, vitamin, esters, purine nucleosides. Additionally, there was a significant increase in autophagosomes, after treatment with YFSJF in PF animals. Interestingly, autophagy dysfunction by the blocker chloroquine (CQ) resulted in collagen deposition and inducing the expression of fibrosis-related genes. In addition, YFSJF-induced autophagy is mediated by the PI3K-AKT-mTOR pathway, and knockdown of PI3K by siRNA up-regulated the expression of autophagy-related genes and down-regulated the expression of collagen in human lung fibroblasts (HLF). Our findings provide a detailed understanding that YFSJF-antifibrotic effects are mainly mediated by triggering autophagy, and suppressing phosphorylation of the PI3K-AKT-mTOR pathway is required for YFSJF-curative effect.
DOI: 10.1016/j.biopha.2019.109293
PubMed: 31401393
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000042
- to stream PubMed, to step Curation: 000042
- to stream PubMed, to step Checkpoint: 000069
- to stream Ncbi, to step Merge: 000901
- to stream Ncbi, to step Curation: 000901
- to stream Ncbi, to step Checkpoint: 000901
- to stream Main, to step Merge: 000A75
- to stream Main, to step Curation: 000A75
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antifibrotic action of Yifei Sanjie formula enhanced autophagy via PI3K-AKT-mTOR signaling pathway in mouse model of pulmonary fibrosis.</title><author><name sortKey="Yu, Jing Ze" sort="Yu, Jing Ze" uniqKey="Yu J" first="Jing-Ze" last="Yu">Jing-Ze Yu</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Ying, Yi" sort="Ying, Yi" uniqKey="Ying Y" first="Yi" last="Ying">Yi Ying</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Chun Bin" sort="Sun, Chun Bin" uniqKey="Sun C" first="Chun-Bin" last="Sun">Chun-Bin Sun</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Dai, Chen" sort="Dai, Chen" uniqKey="Dai C" first="Chen" last="Dai">Chen Dai</name><affiliation wicri:level="1"><nlm:affiliation>Respiratory Department, Zhijiang Hospital of Chinese Medicine, Zhijiang, Hu Bei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Respiratory Department, Zhijiang Hospital of Chinese Medicine, Zhijiang, Hu Bei</wicri:regionArea><wicri:noRegion>Hu Bei</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Shan" sort="Zhao, Shan" uniqKey="Zhao S" first="Shan" last="Zhao">Shan Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology and Immunology Department, The First People's Hosipital of Yunnan Province, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Rheumatology and Immunology Department, The First People's Hosipital of Yunnan Province, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Tian, Shou Zheng" sort="Tian, Shou Zheng" uniqKey="Tian S" first="Shou-Zheng" last="Tian">Shou-Zheng Tian</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Peng, Jing" sort="Peng, Jing" uniqKey="Peng J" first="Jing" last="Peng">Jing Peng</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Han, Ni Ping" sort="Han, Ni Ping" uniqKey="Han N" first="Ni-Ping" last="Han">Ni-Ping Han</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Jia Li" sort="Yuan, Jia Li" uniqKey="Yuan J" first="Jia-Li" last="Yuan">Jia-Li Yuan</name><affiliation wicri:level="1"><nlm:affiliation>Yunnan Key Laboratory of Molecular Biology of Chinese Medicine, Kunming, Yunnan, China. Electronic address: 2748132800@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Yunnan Key Laboratory of Molecular Biology of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Jin Yuan" sort="Yan, Jin Yuan" uniqKey="Yan J" first="Jin-Yuan" last="Yan">Jin-Yuan Yan</name><affiliation wicri:level="1"><nlm:affiliation>Central laboratory, The Second Affiliated Hospital of Kunming Medical Univ-ersity, Kunming, Yunnan, China. Electronic address: 399109308@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Central laboratory, The Second Affiliated Hospital of Kunming Medical Univ-ersity, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Zhong Shan" sort="Yang, Zhong Shan" uniqKey="Yang Z" first="Zhong-Shan" last="Yang">Zhong-Shan Yang</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China. Electronic address: yangzhongshan@ynutcm.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31401393</idno><idno type="pmid">31401393</idno><idno type="doi">10.1016/j.biopha.2019.109293</idno><idno type="wicri:Area/PubMed/Corpus">000042</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000042</idno><idno type="wicri:Area/PubMed/Curation">000042</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000042</idno><idno type="wicri:Area/PubMed/Checkpoint">000069</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000069</idno><idno type="wicri:Area/Ncbi/Merge">000901</idno><idno type="wicri:Area/Ncbi/Curation">000901</idno><idno type="wicri:Area/Ncbi/Checkpoint">000901</idno><idno type="wicri:Area/Main/Merge">000A75</idno><idno type="wicri:Area/Main/Curation">000A75</idno><idno type="wicri:Area/Main/Exploration">000A75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antifibrotic action of Yifei Sanjie formula enhanced autophagy via PI3K-AKT-mTOR signaling pathway in mouse model of pulmonary fibrosis.</title><author><name sortKey="Yu, Jing Ze" sort="Yu, Jing Ze" uniqKey="Yu J" first="Jing-Ze" last="Yu">Jing-Ze Yu</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Ying, Yi" sort="Ying, Yi" uniqKey="Ying Y" first="Yi" last="Ying">Yi Ying</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Chun Bin" sort="Sun, Chun Bin" uniqKey="Sun C" first="Chun-Bin" last="Sun">Chun-Bin Sun</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Dai, Chen" sort="Dai, Chen" uniqKey="Dai C" first="Chen" last="Dai">Chen Dai</name><affiliation wicri:level="1"><nlm:affiliation>Respiratory Department, Zhijiang Hospital of Chinese Medicine, Zhijiang, Hu Bei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Respiratory Department, Zhijiang Hospital of Chinese Medicine, Zhijiang, Hu Bei</wicri:regionArea><wicri:noRegion>Hu Bei</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Shan" sort="Zhao, Shan" uniqKey="Zhao S" first="Shan" last="Zhao">Shan Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology and Immunology Department, The First People's Hosipital of Yunnan Province, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Rheumatology and Immunology Department, The First People's Hosipital of Yunnan Province, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Tian, Shou Zheng" sort="Tian, Shou Zheng" uniqKey="Tian S" first="Shou-Zheng" last="Tian">Shou-Zheng Tian</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Peng, Jing" sort="Peng, Jing" uniqKey="Peng J" first="Jing" last="Peng">Jing Peng</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Han, Ni Ping" sort="Han, Ni Ping" uniqKey="Han N" first="Ni-Ping" last="Han">Ni-Ping Han</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Jia Li" sort="Yuan, Jia Li" uniqKey="Yuan J" first="Jia-Li" last="Yuan">Jia-Li Yuan</name><affiliation wicri:level="1"><nlm:affiliation>Yunnan Key Laboratory of Molecular Biology of Chinese Medicine, Kunming, Yunnan, China. Electronic address: 2748132800@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Yunnan Key Laboratory of Molecular Biology of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Jin Yuan" sort="Yan, Jin Yuan" uniqKey="Yan J" first="Jin-Yuan" last="Yan">Jin-Yuan Yan</name><affiliation wicri:level="1"><nlm:affiliation>Central laboratory, The Second Affiliated Hospital of Kunming Medical Univ-ersity, Kunming, Yunnan, China. Electronic address: 399109308@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Central laboratory, The Second Affiliated Hospital of Kunming Medical Univ-ersity, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Zhong Shan" sort="Yang, Zhong Shan" uniqKey="Yang Z" first="Zhong-Shan" last="Yang">Zhong-Shan Yang</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan, China. Electronic address: yangzhongshan@ynutcm.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Basic Medical Science, Yunnan Univer.0sity of Chinese Medicine, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</title><idno type="eISSN">1950-6007</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Autophagosomes (metabolism)</term><term>Autophagosomes (ultrastructure)</term><term>Autophagy (drug effects)</term><term>Collagen (metabolism)</term><term>Disease Models, Animal</term><term>Drugs, Chinese Herbal</term><term>Humans</term><term>Inflammation (complications)</term><term>Inflammation (pathology)</term><term>Lung (pathology)</term><term>Male</term><term>Phosphatidylinositol 3-Kinases (metabolism)</term><term>Phosphorylation (drug effects)</term><term>Proto-Oncogene Proteins c-akt (metabolism)</term><term>Pulmonary Fibrosis (complications)</term><term>Pulmonary Fibrosis (drug therapy)</term><term>Pulmonary Fibrosis (metabolism)</term><term>Pulmonary Fibrosis (pathology)</term><term>Signal Transduction</term><term>TOR Serine-Threonine Kinases (metabolism)</term><term>Transforming Growth Factor beta1 (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Autophagie ()</term><term>Autophagosomes (métabolisme)</term><term>Autophagosomes (ultrastructure)</term><term>Collagène (métabolisme)</term><term>Facteur de croissance transformant bêta-1 (métabolisme)</term><term>Fibrose pulmonaire ()</term><term>Fibrose pulmonaire (anatomopathologie)</term><term>Fibrose pulmonaire (métabolisme)</term><term>Fibrose pulmonaire (traitement médicamenteux)</term><term>Humains</term><term>Inflammation ()</term><term>Inflammation (anatomopathologie)</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Médicaments issus de plantes chinoises</term><term>Phosphatidylinositol 3-kinases (métabolisme)</term><term>Phosphorylation ()</term><term>Poumon (anatomopathologie)</term><term>Protéines proto-oncogènes c-akt (métabolisme)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Collagen</term><term>Proto-Oncogene Proteins c-akt</term><term>TOR Serine-Threonine Kinases</term><term>Transforming Growth Factor beta1</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Fibrose pulmonaire</term><term>Inflammation</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Inflammation</term><term>Pulmonary Fibrosis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term><term>Phosphorylation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pulmonary Fibrosis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Autophagosomes</term><term>Phosphatidylinositol 3-Kinases</term><term>Pulmonary Fibrosis</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Autophagosomes</term><term>Collagène</term><term>Facteur de croissance transformant bêta-1</term><term>Fibrose pulmonaire</term><term>Phosphatidylinositol 3-kinases</term><term>Protéines proto-oncogènes c-akt</term><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammation</term><term>Lung</term><term>Pulmonary Fibrosis</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Fibrose pulmonaire</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Autophagosomes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Drugs, Chinese Herbal</term><term>Humans</term><term>Male</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Autophagie</term><term>Autophagosomes</term><term>Fibrose pulmonaire</term><term>Humains</term><term>Inflammation</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Médicaments issus de plantes chinoises</term><term>Phosphorylation</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pulmonary fibrosis (PF) is a crippling disease characterized by progressive dyspnea and associated with a high mortality rate, but its origin is unknown and there is no effective treatment. Yifei Sanjie formula (YFSJF) is a Chinese medicine that is widely used for treatment of respiratory systems disease. However, the molecular basis for the function of YFSJF has not been determined. Here we investigate the contribution of YFSJF in BLM-induced PF mice. Administration with YFSJF significantly alleviated the degree of BLM-induced collagen I and III deposition and the inflammatory injuring in the lungs and suppressed hydroxyproline release in PF animals. The active components of YFSJF are comprised with flavonoid, amino acids, saponins, oligosaccharide, organic acid, vitamin, esters, purine nucleosides. Additionally, there was a significant increase in autophagosomes, after treatment with YFSJF in PF animals. Interestingly, autophagy dysfunction by the blocker chloroquine (CQ) resulted in collagen deposition and inducing the expression of fibrosis-related genes. In addition, YFSJF-induced autophagy is mediated by the PI3K-AKT-mTOR pathway, and knockdown of PI3K by siRNA up-regulated the expression of autophagy-related genes and down-regulated the expression of collagen in human lung fibroblasts (HLF). Our findings provide a detailed understanding that YFSJF-antifibrotic effects are mainly mediated by triggering autophagy, and suppressing phosphorylation of the PI3K-AKT-mTOR pathway is required for YFSJF-curative effect.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yu, Jing Ze" sort="Yu, Jing Ze" uniqKey="Yu J" first="Jing-Ze" last="Yu">Jing-Ze Yu</name></noRegion><name sortKey="Dai, Chen" sort="Dai, Chen" uniqKey="Dai C" first="Chen" last="Dai">Chen Dai</name><name sortKey="Han, Ni Ping" sort="Han, Ni Ping" uniqKey="Han N" first="Ni-Ping" last="Han">Ni-Ping Han</name><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><name sortKey="Peng, Jing" sort="Peng, Jing" uniqKey="Peng J" first="Jing" last="Peng">Jing Peng</name><name sortKey="Sun, Chun Bin" sort="Sun, Chun Bin" uniqKey="Sun C" first="Chun-Bin" last="Sun">Chun-Bin Sun</name><name sortKey="Tian, Shou Zheng" sort="Tian, Shou Zheng" uniqKey="Tian S" first="Shou-Zheng" last="Tian">Shou-Zheng Tian</name><name sortKey="Yan, Jin Yuan" sort="Yan, Jin Yuan" uniqKey="Yan J" first="Jin-Yuan" last="Yan">Jin-Yuan Yan</name><name sortKey="Yang, Zhong Shan" sort="Yang, Zhong Shan" uniqKey="Yang Z" first="Zhong-Shan" last="Yang">Zhong-Shan Yang</name><name sortKey="Ying, Yi" sort="Ying, Yi" uniqKey="Ying Y" first="Yi" last="Ying">Yi Ying</name><name sortKey="Yuan, Jia Li" sort="Yuan, Jia Li" uniqKey="Yuan J" first="Jia-Li" last="Yuan">Jia-Li Yuan</name><name sortKey="Zhao, Shan" sort="Zhao, Shan" uniqKey="Zhao S" first="Shan" last="Zhao">Shan Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A75 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A75 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:31401393
|texte= Antifibrotic action of Yifei Sanjie formula enhanced autophagy via PI3K-AKT-mTOR signaling pathway in mouse model of pulmonary fibrosis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31401393" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |